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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303043
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Clic1
Name: chloride intracellular channel 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Clic1affects expressionEXP 6480464CTDCadmium Chloride affects the expression of CLIC1 mRNAPMID:22110744
Clic1decreases methylationEXP 6480464CTDCadmium Chloride results in decreased methylation of CLIC1 promoterPMID:22457795
Clic1multiple interactionsISOCLIC1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CLIC1 proteinPMID:33040242
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