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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of ESR1 proteinPMID:37482142
Esr1affects localizationISOESR1 (Homo sapiens)6480464CTDCadmium Chloride affects the localization of ESR1 proteinPMID:20219890
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of ESR1 proteinPMID:17125913
Esr1decreases methylationISOEsr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of ESR1 promoterPMID:22457795
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDCadmium Chloride results in increased activity of ESR1 proteinPMID:17716812
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of ESR1 mRNA; Cadmium Chloride results in increased expression of ESR1 protein; Cadmium Chloride results in increased expression of ESR1 protein alternative formPMID:24236210 PMID:33453195
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of ESR1 proteinPMID:30682495
Esr1increases splicingISOEsr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased splicing of ESR1 mRNAPMID:24236210
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDCadmium Chloride promotes the reaction [Estradiol results in increased expression of ESR1 mRNA]; Estradiol promotes the reaction [Cadmium Chloride results in increased expression of ESR1 mRNA]PMID:24236210
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased ubiquitination of ESR1 protein; Cadmium Chloride promotes the reaction [ESR1 protein binds to CCND1 promoter]; Cadmium Chloride promotes the reaction [ESR1 protein binds to JUN protein]; Cadmium Chloride promotes the reaction [ESR1 protein binds to MYC promoter]; Cadmium Chloride promotes the reaction [Estradiol results in increased activity of ESR1 protein]; ESR1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; ESR1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]; ESR1 protein alternative form affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP2 protein]; ESR1 protein alternative form affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased activity of MMP9 protein]; ESR1 protein results in increased susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of ESR1 protein]PMID:20219890 PMID:27514991 PMID:30682495 PMID:31468104 PMID:31689473 PMID:33040242
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