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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10440 Species: Mus musculus RGD Object: Gene Symbol: Cyp21a1 Name: cytochrome P450, family 21, subfamily a, polypeptide 1

Acc ID: CHEBI:35456 Term: cadmium dichloride Definition: A cadmium coordination entity that has formula CdCl2. CasRN: 10108-64-2 Chemical ID: MESH:D019256

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Cadmium Chloride results in decreased expression of CYP21A1 mRNA	PMID:11958953
decreases methylation	ISO	RGD:2461	6480464	CTD	Cadmium Chloride results in decreased methylation of CYP21A1 promoter	PMID:22457795