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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1a2 Name: cytochrome P450, family 1, subfamily a, polypeptide 2

Acc ID: CHEBI:35298 Term: anthracene Definition: Polycyclic aromatic hydrocarbon comprising three fused benzene rings. CasRN: 120-12-7 Chemical ID: MESH:C034020

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:10438	6480464	CTD	anthracene results in increased activity of CYP1A2 protein	PMID:8001243
increases activity	ISO	RGD:735711	6480464	CTD	anthracene results in increased activity of CYP1A2 protein	PMID:19362136
multiple interactions	ISO	RGD:735711	6480464	CTD	alyssin inhibits the reaction [anthracene results in increased activity of CYP1A2 protein] sulforafan inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]	PMID:19362136
multiple interactions	ISO	RGD:10438	6480464	CTD	[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA	PMID:7750161