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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305098
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc30a10
Name: solute carrier family 30, member 10
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc30a10affects transportISOSLC30A10 (Homo sapiens)6480464CTDSLC30A10 gene SNP affects the transport of ManganesePMID:26025379
Slc30a10decreases abundanceISOSLC30A10 (Homo sapiens)6480464CTDSLC30A10 gene SNP results in decreased abundance of ManganesePMID:26628504
Slc30a10decreases expressionISOSlc30a10 (Mus musculus)6480464CTDManganese results in decreased expression of SLC30A10 mRNAPMID:29020610
Slc30a10increases abundanceISOSLC30A10 (Homo sapiens)6480464CTDSLC30A10 gene mutant form results in increased abundance of Manganese; SLC30A10 gene SNP results in increased abundance of ManganesePMID:22926781 PMID:26628504
Slc30a10increases secretionISOSLC30A10 (Homo sapiens)6480464CTDSLC30A10 protein results in increased secretion of ManganesePMID:28860195
Slc30a10multiple interactionsISOSlc30a10 (Mus musculus)6480464CTD[manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC30A10 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of SLC30A10 proteinPMID:34590183
Slc30a10multiple interactionsISOSLC30A10 (Homo sapiens)6480464CTD[IL6 protein results in decreased expression of SLC30A10 mRNA] which results in decreased export of Manganese; [IL6 protein results in decreased expression of SLC30A10 protein] which results in decreased export of Manganese; Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]PMID:22926781 PMID:24576911
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