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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:351346
Term: phenethyl isothiocyanate
Definition: An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.
Chemical ID: MESH:C058305
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases expressionEXP 6480464CTDphenethyl isothiocyanate results in decreased expression of CYP1A2 proteinPMID:20025923
Cyp1a2increases expressionEXP 6480464CTDphenethyl isothiocyanate results in increased expression of CYP1A2 mRNAPMID:22664424
Cyp1a2multiple interactionsEXP 6480464CTDphenethyl isothiocyanate results in increased activity of [CYP1A1 protein co-treated with CYP1A2 protein]PMID:22664424
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDphenethyl isothiocyanate results in decreased activity of CYP1A2 mRNAPMID:20442190
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDphenethyl isothiocyanate results in decreased expression of CYP1A2 proteinPMID:20025923
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDphenethyl isothiocyanate results in increased expression of CYP1A2 mRNAPMID:15672752 PMID:20442190
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