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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:35036
Term: fentin chloride
Definition: An organotin compound that is triphenylstannane in which the hydrogen attached to tin is replaced by a chloro group. A fungicide used to control blights on potatoes, leaf spot diseases on sugar beet and anthracnose on beans.
Chemical ID: MESH:C012594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxraincreases expressionEXP 6480464CTDtriphenyltin chloride results in increased expression of RXRA proteinPMID:37156404
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTDRXRA protein affects the reaction [triphenyltin chloride results in increased expression of and results in increased activity of HSD11B2 protein]; RXRA protein affects the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA]; triphenyltin chloride inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin chloride inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]PMID:15941851 PMID:31927052
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