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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:35036
Term: fentin chloride
Definition: An organotin compound that is triphenylstannane in which the hydrogen attached to tin is replaced by a chloro group. A fungicide used to control blights on potatoes, leaf spot diseases on sugar beet and anthracnose on beans.
Chemical ID: MESH:C012594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargmultiple interactionsEXP 6480464CTDtriphenyltin chloride results in increased expression of and affects the localization of PPARG proteinPMID:37156404
Ppargincreases activityISOPPARG (Homo sapiens)6480464CTDtriphenyltin chloride results in increased activity of PPARG proteinPMID:26172262
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDtriphenyltin chloride results in increased expression of PPARG proteinPMID:37142754
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDdiphenyltin chloride inhibits the reaction [triphenyltin chloride binds to PPARG protein]; tetrabutyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]; tributyltin inhibits the reaction [triphenyltin chloride binds to PPARG protein]; triphenyltin chloride binds to and results in increased activity of PPARG protein; triphenyltin chloride inhibits the reaction [Rosiglitazone binds to PPARG protein]PMID:19497422 PMID:33049310
Ppargmultiple interactionsISOPparg (Mus musculus)6480464CTD[triphenyltin chloride co-treated with tributyltin co-treated with dibutyldichlorotin] results in increased expression of PPARG protein; triphenyltin chloride binds to and results in increased activity of PPARG protein; triphenyltin chloride inhibits the reaction [Dexamethasone results in increased expression of PPARG protein]; triphenyltin chloride inhibits the reaction [Rosiglitazone results in increased expression of PPARG protein]PMID:33049310 PMID:37142754
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