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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621157
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txn1
Name: thioredoxin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txn1increases expressionEXP 6480464CTDParaquat results in increased expression of TXN1 mRNAPMID:16328009
Txn1decreases response to substanceISOTXN (Homo sapiens)6480464CTDTXN protein results in decreased susceptibility to ParaquatPMID:10754530 PMID:16024017 PMID:19735704
Txn1increases expressionISOTxn1 (Mus musculus)6480464CTDParaquat results in increased expression of TXN1 mRNAPMID:17215068
Txn1increases oxidationISOTXN (Homo sapiens)6480464CTDParaquat results in increased oxidation of TXN1 proteinPMID:21402726
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