Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDParaquat affects the expression of HMOX1 mRNA; Paraquat affects the expression of HMOX1 proteinPMID:16854511 PMID:31715309
Hmox1decreases expressionEXP 6480464CTDParaquat results in decreased expression of HMOX1 mRNA; Paraquat results in decreased expression of HMOX1 proteinPMID:35236239
Hmox1increases activityEXP 6480464CTDParaquat results in increased activity of HMOX1 proteinPMID:12180188 PMID:25169090
Hmox1increases expressionEXP 6480464CTDParaquat results in increased expression of HMOX1; Paraquat results in increased expression of HMOX1 mRNA; Paraquat results in increased expression of HMOX1 proteinPMID:15527874 PMID:16328009 PMID:16555045 PMID:17935786 PMID:19080378 PMID:20095327 PMID:20600150 PMID:22983789 PMID:24521700 PMID:24812154 PMID:26598004 PMID:28467894 PMID:30112919 PMID:32680482 PMID:35707280
Hmox1multiple interactionsEXP 6480464CTD[Mifepristone co-treated with Paraquat] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with ginkgolide C] results in increased expression of HMOX1 protein; [Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of HMOX1 mRNA; alpha-Tocopherol inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Curcumin inhibits the reaction [Paraquat results in increased activity of HMOX1 protein]; Estradiol affects the reaction [Paraquat affects the expression of HMOX1 protein]; ginkgolide C promotes the reaction [Paraquat results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; MIR136 promotes the reaction [Paraquat results in decreased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Paraquat results in increased expression of HMOX1]; Resveratrol inhibits the reaction [MIR136 promotes the reaction [Paraquat results in decreased expression of HMOX1 protein]]; Resveratrol inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; SB 203580 promotes the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of HMOX1 mRNA]PMID:12180188 PMID:19080378 PMID:20600150 PMID:24376630 PMID:24812154 PMID:25169090 PMID:31715309 PMID:35236239 PMID:35707280
Hmox1affects activityISOHmox1 (Mus musculus)6480464CTDParaquat affects the activity of HMOX1 proteinPMID:26935021
Hmox1affects expressionISOHmox1 (Mus musculus)6480464CTDParaquat affects the expression of HMOX1 mRNAPMID:27788593
Hmox1affects expressionISOHMOX1 (Homo sapiens)6480464CTDParaquat affects the expression of HMOX1 mRNAPMID:23546295
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDParaquat results in decreased expression of HMOX1 mRNA; Paraquat results in decreased expression of HMOX1 proteinPMID:23603004 PMID:26758514 PMID:30562684 PMID:30571954 PMID:33838153
Hmox1increases activityISOHmox1 (Mus musculus)6480464CTDParaquat results in increased activity of HMOX1 proteinPMID:26708779
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDParaquat results in increased expression of HMOX1 mRNA; Paraquat results in increased expression of HMOX1 proteinPMID:11181820 PMID:17215068 PMID:18620719 PMID:22983789 PMID:29950142 PMID:31216030
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDParaquat results in increased expression of HMOX1 mRNA; Paraquat results in increased expression of HMOX1 proteinPMID:15728566 PMID:16263688 PMID:17409708 PMID:22493042 PMID:22709784 PMID:22996356 PMID:23546295 PMID:26649146 PMID:35182771
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of HMOX1 protein]; [SIRT6 protein mutant form results in decreased activity of SIRT6 protein] inhibits the reaction [Paraquat promotes the reaction [SMARCA4 protein binds to HMOX1 enhancer]]; [SIRT6 protein mutant form results in decreased activity of SIRT6 protein] inhibits the reaction [Paraquat results in increased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of HMOX1 protein]; Paraquat affects the reaction [APOD protein affects the expression of HMOX1 protein]; Paraquat promotes the reaction [POLR2A protein modified form binds to HMOX1 gene]; Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]; Paraquat promotes the reaction [SMARCA4 protein binds to HMOX1 enhancer]; Paraquat promotes the reaction [SMARCC2 protein binds to HMOX1 enhancer]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; resolvin D1 analog inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; resolvin D1 inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; Resveratrol promotes the reaction [Paraquat results in increased activity of HMOX1 protein]; rhyncophylline inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; SIRT1 protein affects the reaction [Paraquat affects the activity of HMOX1 protein]; SIRT6 promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [POLR2A protein modified form binds to HMOX1 gene]]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [SMARCA4 protein binds to HMOX1 enhancer]]; SIRT6 protein promotes the reaction [Paraquat promotes the reaction [SMARCC2 protein binds to HMOX1 enhancer]]; SMARCC2 protein mutant form inhibits the reaction [Paraquat results in increased expression of HMOX1 mRNA]; SMARCC2 protein promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]PMID:21688324 PMID:22983789 PMID:23603004 PMID:26708779 PMID:26758514 PMID:26935021 PMID:29950142 PMID:30562684 PMID:30571954 PMID:31216030 PMID:33838153
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Paraquat co-treated with Antigens, Dermatophagoides] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Ellagic Acid] results in increased expression of HMOX1 protein; [Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; [Quercetin co-treated with Paraquat] results in increased expression of HMOX1 protein; [SIRT6 protein results in decreased susceptibility to Paraquat] inhibits the reaction [NFE2L2 protein binds to HMOX1 enhancer]; [SNCA protein co-treated with Paraquat co-treated with Dopamine] results in increased expression of HMOX1 protein; NFE2L2 mRNA promotes the reaction [Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]]; Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]; Resveratrol promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; Silymarin promotes the reaction [Paraquat results in increased expression of HMOX1 mRNA]; Silymarin promotes the reaction [Paraquat results in increased expression of HMOX1 protein]PMID:21735318 PMID:22493042 PMID:22709784 PMID:22996356 PMID:23546295 PMID:23649336 PMID:24561720 PMID:31216030 PMID:34097952
Go Back to source page   Continue to Ontology report