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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2218
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Brca1
Name: BRCA1, DNA repair associated
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Brca1decreases response to substanceISOBRCA1 (Homo sapiens)6480464CTDBRCA1 protein results in decreased susceptibility to ParaquatPMID:15520196
Brca1multiple interactionsISOBrca1 (Mus musculus)6480464CTD[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of BRCA1 mRNAPMID:28012437
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