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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases activityISOMMP9 (Homo sapiens)6480464CTDnickel chloride results in increased activity of MMP9 proteinPMID:26962057
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDnickel chloride results in increased expression of MMP9 proteinPMID:21473897
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDchrysin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; nickel chloride results in increased expression of and results in increased activity of MMP9 protein; Quercetin inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]; SC 514 inhibits the reaction [nickel chloride results in increased expression of and results in increased activity of MMP9 protein]PMID:30016632
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