GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects expression | EXP | | 6480464 | CTD | nickel chloride affects the expression of TP53 mRNA | PMID:22546817 | Tp53 | decreases activity | ISO | TP53 (Homo sapiens) | 6480464 | CTD | nickel chloride results in decreased activity of TP53 protein | PMID:25446071 | Tp53 | decreases response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 mutant form results in decreased susceptibility to nickel chloride | PMID:23566959 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | nickel chloride results in increased expression of TRP53 mRNA; nickel chloride results in increased expression of TRP53 protein | PMID:12426141 PMID:12839937 PMID:36421005 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased expression of TP53 protein; nickel chloride results in increased expression of TP53 protein modified form | PMID:23566959 PMID:28552779 PMID:29110037 | Tp53 | increases phosphorylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | nickel chloride results in increased phosphorylation of TP53 protein | PMID:21466819 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 mRNA]]; TXNRD3 gene mutant form inhibits the reaction [Melatonin inhibits the reaction [nickel chloride results in increased expression of TRP53 protein]]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of TRP53 mRNA]; TXNRD3 gene mutant form promotes the reaction [nickel chloride results in increased expression of TRP53 protein] | PMID:36421005 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [nickel chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]; [nickel chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]; [nickel chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]; [TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]] which results in decreased cleavage of CASP3 protein; [TP53 mutant form results in decreased susceptibility to nickel chloride] which results in decreased cleavage of PARP1 protein; nickel chloride results in increased phosphorylation of and results in increased activity of TP53 protein; TP53 mutant form inhibits the reaction [nickel chloride results in increased activity of CASP9 protein]; TP53 protein affects the reaction [nickel chloride results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of BTG2 mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of CDKN1A mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of MCL1 mRNA]; TP53 protein affects the reaction [nickel chloride results in increased expression of MDM2 mRNA] | PMID:23566959 PMID:25446071 | | ||||||||||||||||||||||
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