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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldha
Name: lactate dehydrogenase A
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhaincreases expressionEXP 6480464CTDnickel chloride results in increased expression of LDHA mRNAPMID:22110744
Ldhaincreases expressionISOLdha (Mus musculus)6480464CTDnickel chloride results in increased expression of LDHA mRNAPMID:12426141 PMID:12729255 PMID:12839937 PMID:27452194
Ldhaincreases expressionISOLDHA (Homo sapiens)6480464CTDnickel chloride results in increased expression of LDHA mRNAPMID:33596451
Ldhamultiple interactionsISOLdha (Mus musculus)6480464CTDDinoprostone promotes the reaction [nickel chloride results in increased expression of LDHA mRNA]; HIF1A affects the reaction [nickel chloride results in increased expression of LDHA mRNA]PMID:12426141 PMID:12729255 PMID:27452194
Ldhamultiple interactionsISOLDHA (Homo sapiens)6480464CTD2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide inhibits the reaction [nickel chloride results in increased expression of LDHA mRNA]PMID:33596451
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