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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731982
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Acc ID: CHEBI:34879
Term: NS 1619
Definition: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Chemical ID: MESH:C086491
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnma1multiple interactionsISOKCNMA1 (Homo sapiens)6480464CTDNS 1619 binds to and results in increased activity of KCNMA1 protein; NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]PMID:21413024
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