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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70494
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tertincreases activityEXP 6480464CTDDiethylnitrosamine results in increased activity of TERT proteinPMID:15682466
Tertincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of TERT mRNAPMID:15682466
Tertmultiple interactionsEXP 6480464CTDfumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA]PMID:15682466
Tertincreases expressionISOTert (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of TERT proteinPMID:19919837
Tertmultiple interactionsISOTert (Mus musculus)6480464CTDATM protein promotes the reaction [Diethylnitrosamine results in increased expression of TERT protein]PMID:19919837
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