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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of PON1 mRNAPMID:19041683
Pon1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PON1 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of PON1 proteinPMID:17602206 PMID:20935162
Pon1decreases expressionISOPon1 (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of PON1 mRNAPMID:24535843
Pon1multiple interactionsISOPon1 (Mus musculus)6480464CTD[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PON1 protein; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PON1 proteinPMID:23457121
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