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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2605 Species: Rattus norvegicus RGD Object: Gene Symbol: Fgf1 Name: fibroblast growth factor 1 (acidic)

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:10577	6480464	CTD	Diethylnitrosamine results in increased expression of FGF1 mRNA	PMID:18691550
multiple interactions	ISO	RGD:10577	6480464	CTD	MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FGF1 mRNA]	PMID:18691550
multiple interactions	EXP		6480464	CTD	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF1 mRNA	PMID:22129741