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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343162 Species: Homo sapiens RGD Object: Gene Symbol: CASP4 Name: caspase 4, apoptosis-related cysteine peptidase

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:621757	6480464	CTD	Ascorbic Acid inhibits the reaction [[kojic acid co-treated with Diethylnitrosamine] results in increased expression of CASP4 mRNA]	PMID:18544905
multiple interactions	ISO	RGD:621757	6480464	CTD	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CASP4 mRNA	PMID:17602206