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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313525 Species: Homo sapiens RGD Object: Gene Symbol: MKI67 Name: antigen identified by monoclonal antibody Ki-67

Acc ID: CHEBI:34873 Term: N-nitrosodiethylamine Definition: A nitrosamine that has formula C4H10N2O. CasRN: 55-18-5 Chemical ID: MESH:D004052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1313526	6480464	CTD	Diethylnitrosamine results in increased expression of MKI67 mRNA	PMID:17854601
increases expression	ISO	RGD:1313526	6480464	CTD	Diethylnitrosamine results in increased expression of MKI67 protein	PMID:17942915
multiple interactions	ISO	RGD:1313526	6480464	CTD	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 mRNA]	PMID:17854601
multiple interactions	ISO	RGD:1313526	6480464	CTD	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of MKI67 protein]	PMID:17942915
multiple interactions	ISO	RGD:1305476	6480464	CTD	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein [Diethylnitrosamine co-treated with Cyclohexanols] results in increased expression of MKI67 protein	PMID:17393424
multiple interactions	ISO	RGD:1305476	6480464	CTD	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MKI67 protein	PMID:17651763
increases expression	EXP		6480464	CTD	Diethylnitrosamine results in increased expression of MKI67 protein	PMID:21776270