GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that has formula C4H10N2O.
CasRN: 55-18-5
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA

[Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA

[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA

PMID:17917374
multiple interactionsEXP 6480464CTDIKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP7A1 mRNA]

PMID:18691550
multiple interactionsISORGD:24826480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA

PMID:16158176
multiple interactionsISORGD:24826480464CTD[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA

PMID:14656948
increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of CYP7A1 mRNA

PMID:18691550
multiple interactionsISORGD:24826480464CTD[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA

PMID:18253720
decreases expressionISORGD:24826480464CTDDiethylnitrosamine results in decreased expression of CYP7A1 mRNA

PMID:19638242
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