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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733809 Species: Homo sapiens RGD Object: Gene Symbol: SLC6A3 Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Acc ID: CHEBI:34785 Term: heptachlor Definition: A cyclodiene organochlorine insecticide that has formula C10H5Cl7. CasRN: 76-44-8 Chemical ID: MESH:D006533

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:11315	6480464	CTD	Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]	PMID:11294980
increases expression	ISO	RGD:3715	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:11719704
increases expression	ISO	RGD:11315	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:11294980 PMID:12428726 PMID:10499361 PMID:16112329
increases expression	ISO	RGD:11315	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:11294980 PMID:10499361 PMID:12428726 PMID:16112329
increases expression	ISO	RGD:11315	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:12428726 PMID:16112329 PMID:10499361 PMID:11294980
increases expression	ISO	RGD:11315	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:11294980 PMID:16112329 PMID:10499361 PMID:12428726
increases expression	ISO	RGD:11315	6480464	CTD	Heptachlor results in increased expression of SLC6A3 protein	PMID:10499361 PMID:11294980 PMID:12428726 PMID:16112329