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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736157 Species: Homo sapiens RGD Object: Gene Symbol: ABCA1 Name: ATP-binding cassette, sub-family A (ABC1), member 1

Acc ID: CHEBI:34779 Term: glyoxal Definition: The smallest possible dialdehyde which consists of ethane having oxo groups on both carbons. CasRN: 107-22-2 Chemical ID: MESH:D006037

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]	PMID:15983222
multiple interactions	ISO	RGD:1332354	6480464	CTD	Glyoxal inhibits the reaction [ABCA1 protein binds to APOA1 protein]	PMID:15983222
increases degradation	ISO	RGD:1332354	6480464	CTD	Glyoxal results in increased degradation of ABCA1 protein	PMID:15983222