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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd86
Name: CD86 molecule
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd86affects expressionISOCD86 (Homo sapiens)6480464CTDDinitrochlorobenzene affects the expression of CD86 proteinPMID:30842373
Cd86affects expressionISOCd86 (Mus musculus)6480464CTDDinitrochlorobenzene affects the expression of CD86 mRNAPMID:28219650
Cd86increases expressionISOCD86 (Homo sapiens)6480464CTDDinitrochlorobenzene results in increased expression of CD86 mRNA; Dinitrochlorobenzene results in increased expression of CD86 proteinPMID:12423654 PMID:15737199 PMID:17374397 PMID:17636246 PMID:19033392 PMID:19665512 PMID:20417223 PMID:20457211 PMID:20488241 PMID:21742781 PMID:24136171 PMID:28389280 PMID:29743441 PMID:33774146
Cd86multiple interactionsISOCD86 (Homo sapiens)6480464CTDAcetylcysteine affects the reaction [Dinitrochlorobenzene affects the expression of CD86 protein]; Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; bisindolylmaleimide I inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; cariporide inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Citric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Cysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Lactic Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Vitamin E inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]PMID:19033392 PMID:20417223 PMID:20457211 PMID:24136171 PMID:29743441 PMID:30842373
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