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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2343 Species: Rattus norvegicus RGD Object: Gene Symbol: Chrm3 Name: cholinergic receptor, muscarinic 3

Acc ID: CHEBI:34714 Term: dimethoate Definition: An organothiophosphate insecticide that has formula C5H12NO3PS2. CasRN: 60-51-5 Chemical ID: MESH:D004117

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:734195	6480464	CTD	Dimethoate results in increased expression of CHRM3 mRNA	PMID:15033005
decreases expression	EXP		6480464	CTD	Dimethoate results in decreased expression of CHRM3 mRNA	PMID:15033006