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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:34687
Term: dibutyl phthalate
Definition: A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.
Chemical ID: MESH:D003993
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases activityEXP 6480464CTDDibutyl Phthalate results in decreased activity of SOD2 proteinPMID:25172463
Sod2decreases expressionEXP 6480464CTDDibutyl Phthalate results in decreased expression of SOD2 mRNAPMID:21266533 PMID:32525071
Sod2multiple interactionsEXP 6480464CTDtaxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]PMID:32525071
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