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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1decreases expressionEXP 6480464CTDDiazinon results in decreased expression of PON1 mRNAPMID:29383019
Pon1affects metabolic processingISOPON1 (Homo sapiens)6480464CTDPON1 protein affects the metabolism of DiazinonPMID:16002382 PMID:16027737
Pon1affects response to substanceISOPON1 (Homo sapiens)6480464CTDPON1 gene polymorphism affects the susceptibility to Diazinon; PON1 protein affects the susceptibility to Diazinon; PON1 protein polymorphism affects the susceptibility to DiazinonPMID:11888590 PMID:15864126 PMID:19907334 PMID:31981688
Pon1increases hydrolysisISOPON1 (Homo sapiens)6480464CTDPON1 protein results in increased hydrolysis of DiazinonPMID:16331452
Pon1increases response to substanceISOPon1 (Mus musculus)6480464CTDPON1 gene mutant form results in increased susceptibility to DiazinonPMID:11022865
Pon1multiple interactionsISOPON1 (Homo sapiens)6480464CTDPON1 protein polymorphism inhibits the reaction [Diazinon results in decreased activity of ACHE protein]PMID:31981688
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