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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects expressionEXP 6480464CTDDiazinon affects the expression of TP53 mRNAPMID:22546817
Tp53increases expressionEXP 6480464CTDDiazinon results in increased expression of TP53 mRNAPMID:17452286
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDDiazinon results in increased expression of TP53 mRNAPMID:27920530
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[Selenium analog co-treated with Magnesium Oxide analog] inhibits the reaction [Diazinon results in increased expression of TP53 mRNA]; Magnesium Oxide analog inhibits the reaction [Diazinon results in increased expression of TP53 mRNA]PMID:27920530
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