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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10916 Species: Mus musculus RGD Object: Gene Symbol: Mpo Name: myeloperoxidase

Acc ID: CHEBI:34674 Term: dextran sulfate Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units. CasRN: 9042-14-2 Chemical ID: MESH:D016264

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1592081	6480464	CTD	Oligosaccharides inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:16375993
increases activity	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:16375993 PMID:15339030
multiple interactions	ISO	RGD:1592081	6480464	CTD	zileuton inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:15339030
multiple interactions	EXP		6480464	CTD	17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] resolvin D1 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] resolvin D2 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:21724996
increases activity	EXP		6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:21724996
increases activity	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:15339030 PMID:16375993
increases expression	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased expression of MPO protein	PMID:21893696
multiple interactions	ISO	RGD:1592081	6480464	CTD	rosiglitazone inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein]	PMID:21893696
multiple interactions	ISO	RGD:1592081	6480464	CTD	Capsaicin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] lafutidine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:15573930
increases activity	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:15339030 PMID:15573930 PMID:16375993
increases activity	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:16375993 PMID:15339030 PMID:15573930
increases activity	ISO	RGD:1592081	6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:15573930 PMID:15339030 PMID:16375993
increases activity	EXP		6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:20637373 PMID:21724996
multiple interactions	EXP		6480464	CTD	resveratrol inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:20637373
increases expression	EXP		6480464	CTD	Dextran Sulfate results in increased expression of MPO protein	PMID:23261717
increases activity	EXP		6480464	CTD	Dextran Sulfate results in increased activity of MPO protein	PMID:20637373 PMID:21724996 PMID:23261679
multiple interactions	EXP		6480464	CTD	monotropein inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]	PMID:23261679