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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:34671
Term: Deoxycorticosterone acetate
Definition: A corticosteroid hormone that has formula C23H32O4.
Chemical ID: MESH:D064791
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases expressionEXP 6480464CTDDesoxycorticosterone Acetate results in increased expression of EDN1 proteinPMID:23089228
Edn1multiple interactionsEXP 6480464CTD[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of EDN1 protein; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA; [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 protein; [Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 mRNA]; [Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDN1 protein]; chromium mesoporphyrin inhibits the reaction [heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]]; chromium mesoporphyrin promotes the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]; heme arginate inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of EDN1 protein]PMID:23089228 PMID:26550192 PMID:7721389
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