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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects expressionEXP 6480464CTDChlorpyrifos affects the expression of CASP9 mRNAPMID:17452286
Casp9increases activityEXP 6480464CTDChlorpyrifos results in increased activity of CASP9 proteinPMID:22714038 PMID:27941166
Casp9increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of CASP9 proteinPMID:30990955
Casp9multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Chlorpyrifos results in increased activity of CASP9 protein]; Quercetin inhibits the reaction [Chlorpyrifos results in increased expression of CASP9 protein]PMID:22714038 PMID:30990955
Casp9affects expressionISOCasp9 (Mus musculus)6480464CTDChlorpyrifos affects the expression of CASP9 mRNA; Chlorpyrifos affects the expression of CASP9 proteinPMID:29156651 PMID:33349080
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDChlorpyrifos results in increased cleavage of CASP9 proteinPMID:36811218
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDChlorpyrifos results in increased cleavage of CASP9 proteinPMID:24793810
Casp9increases expressionISOCasp9 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of CASP9 mRNAPMID:30378422 PMID:32149475
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CASP9 protein; Chlorpyrifos results in increased expression of CASP9 protein modified formPMID:23416140 PMID:26435000
Casp9multiple interactionsISOCasp9 (Mus musculus)6480464CTDginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP9 protein]PMID:36811218
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[Chlorpyrifos affects the localization of CASP9 protein] which results in increased activity of CYCS protein; MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of CASP9 protein]PMID:23416140 PMID:26435000
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