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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of TP53 mRNAPMID:12464398 PMID:17452286
Tp53affects activityISOTP53 (Homo sapiens)6480464CTDChlorpyrifos metabolite affects the activity of TP53 proteinPMID:35435491
Tp53affects expressionISOTrp53 (Mus musculus)6480464CTDChlorpyrifos affects the expression of TRP53 mRNAPMID:30378422
Tp53decreases expressionISOTrp53 (Mus musculus)6480464CTDChlorpyrifos results in decreased expression of TRP53 mRNAPMID:30378422
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of TP53 proteinPMID:27993609
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of TRP53 mRNA; Chlorpyrifos results in increased expression of TRP53 proteinPMID:32120800 PMID:34289071
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of TP53 mRNAPMID:30981936
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDBBC3 gene mutant form inhibits the reaction [Chlorpyrifos results in increased expression of TRP53 mRNA]; Plant Extracts inhibits the reaction [Chlorpyrifos results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Chlorpyrifos results in increased expression of TRP53 protein]PMID:32120800 PMID:34289071
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Cisplatin] which results in decreased expression of TP53 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of TP53 mRNA; [[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Temozolomide] which results in decreased expression of TP53 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chlorpyrifos results in decreased expression of TP53 protein]; Cycloheximide promotes the reaction [Chlorpyrifos results in decreased expression of TP53 protein]PMID:27993609 PMID:32800223
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