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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDChlorpyrifos results in decreased activity of CYP2E1 proteinPMID:22634058
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDChlorpyrifos inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]PMID:22634058
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