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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of ChlorpyrifosPMID:15557345 PMID:17079358
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDChlorpyrifos results in decreased activity of CYP1A2 proteinPMID:16790556 PMID:20183062 PMID:22634058
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of CYP1A2 proteinPMID:21784029
Cyp1a2increases expressionISOCyp1a2 (Mus musculus)6480464CTDChlorpyrifos results in increased expression of CYP1A2 mRNAPMID:29097212
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of CYP1A2 mRNAPMID:16190164 PMID:19326769 PMID:21784029 PMID:22310298
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTD[Dietary Fats results in increased susceptibility to Chlorpyrifos] which results in decreased expression of CYP1A2 mRNA; Chlorpyrifos inhibits the reaction [Dietary Fats results in decreased expression of CYP1A2 mRNA]PMID:29097212 PMID:29935250
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDChlorpyrifos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]PMID:16790556
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