GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a2 | affects metabolic processing | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | CYP1A2 protein affects the metabolism of Chlorpyrifos | PMID:15557345 PMID:17079358 | Cyp1a2 | decreases activity | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Chlorpyrifos results in decreased activity of CYP1A2 protein | PMID:16790556 PMID:20183062 PMID:22634058 | Cyp1a2 | decreases expression | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Chlorpyrifos results in decreased expression of CYP1A2 protein | PMID:21784029 | Cyp1a2 | increases expression | ISO | Cyp1a2 (Mus musculus) | 6480464 | CTD | Chlorpyrifos results in increased expression of CYP1A2 mRNA | PMID:29097212 | Cyp1a2 | increases expression | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Chlorpyrifos results in increased expression of CYP1A2 mRNA | PMID:16190164 PMID:19326769 PMID:21784029 PMID:22310298 | Cyp1a2 | multiple interactions | ISO | Cyp1a2 (Mus musculus) | 6480464 | CTD | [Dietary Fats results in increased susceptibility to Chlorpyrifos] which results in decreased expression of CYP1A2 mRNA; Chlorpyrifos inhibits the reaction [Dietary Fats results in decreased expression of CYP1A2 mRNA] | PMID:29097212 PMID:29935250 | Cyp1a2 | multiple interactions | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Chlorpyrifos inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol] | PMID:16790556 | |
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