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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310267
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tfap2a
Name: transcription factor AP-2 alpha
Acc ID: CHEBI:34595
Term: Butylbenzyl phthalate
Definition: A benzyl ester that has formula C19H20O4.
Chemical ID: MESH:C027561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tfap2aaffects localizationISOTFAP2A (Homo sapiens)6480464CTDbutylbenzyl phthalate affects the localization of TFAP2A proteinPMID:22552774
Tfap2amultiple interactionsISOTFAP2A (Homo sapiens)6480464CTD[butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]] which results in increased expression of HDAC6 mRNA; butylbenzyl phthalate promotes the reaction [TFAP2A protein binds to HDAC6 promoter]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]; RTKI cpd inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]; TFAP2A mutant form inhibits the reaction [butylbenzyl phthalate results in increased expression of HDAC6 protein]PMID:22552774
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