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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionEXP 6480464CTD4,4'-bisphenol F results in decreased expression of PTGS2 mRNAPMID:26186136
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTD4,4'-bisphenol F results in increased expression of PTGS2 mRNA; 4,4'-bisphenol F results in increased expression of PTGS2 protein; bisphenol F results in increased expression of PTGS2 mRNAPMID:30951980 PMID:32044397
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of PTGS2 mRNA; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 protein]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 mRNA]; Fulvestrant inhibits the reaction [4,4'-bisphenol F results in increased expression of PTGS2 protein]PMID:30951980 PMID:32044397
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