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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDbisphenol F results in decreased activity of CYP1A2 proteinPMID:33312107
Cyp1a2increases glutathionylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased glutathionylation of 4,4'-bisphenol FPMID:23470418
Cyp1a2increases hydroxylationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased hydroxylation of 4,4'-bisphenol FPMID:23470418
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