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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2686
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gh1
Name: growth hormone 1
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gh1increases expressionEXP 6480464CTD4-nonylphenol results in increased expression of GH1 mRNA; 4-nonylphenol results in increased expression of GH1 proteinPMID:19145065 PMID:19463694
Gh1increases secretionEXP 6480464CTD4-nonylphenol results in increased secretion of GH1 proteinPMID:19463694
Gh1multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]PMID:19145065 PMID:19463694
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