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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:3441
Term: carvedilol
Definition: A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Chemical ID: MESH:C043211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expression EXP 30296650RGDcarvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats 
Tgfb1decreases expressionEXP 6480464CTDcarvedilol results in decreased expression of TGFB1 mRNA; carvedilol results in decreased expression of TGFB1 proteinPMID:16310260 PMID:19692266
Tgfb1multiple interactionsEXP 6480464CTDCarvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Sodium, Dietary results in increased expression of TGFB1 mRNA]PMID:11682445 PMID:22413959 PMID:30254303
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDcarvedilol results in decreased expression of TGFB1 mRNAPMID:11688356 PMID:12227681
Tgfb1decreases expressionISOTgfb1 (Mus musculus)6480464CTDcarvedilol results in decreased expression of TGFB1 mRNAPMID:15921778
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