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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionISOPgr (Mus musculus)6480464CTDbisphenol S results in increased expression of PGR proteinPMID:29526645
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDbisphenol S results in increased expression of PGR mRNA; bisphenol S results in increased expression of PGR proteinPMID:28591870 PMID:29389661 PMID:31388671 PMID:34831106
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [bisphenol S results in increased expression of PGR mRNA]PMID:29389661 PMID:34831106
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