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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735704 Species: Homo sapiens RGD Object: Gene Symbol: PSMB5 Name: proteasome (prosome, macropain) subunit, beta type, 5

Acc ID: CHEBI:34342 Term: 3-methylcholanthrene Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position. CasRN: 56-49-5 Chemical ID: MESH:D008748

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	ISO	RGD:62171	6480464	CTD	Methylcholanthrene results in increased activity of PSMB5 protein	PMID:16723119
increases expression	ISO	RGD:62171	6480464	CTD	Methylcholanthrene results in increased expression of PSMB5 mRNA Methylcholanthrene results in increased expression of PSMB5 protein	PMID:16723119
multiple interactions	ISO	RGD:62171	6480464	CTD	NFE2L2 protein affects the reaction [Methylcholanthrene results in increased expression of PSMB5 mRNA]	PMID:16723119