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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736446 Species: Homo sapiens RGD Object: Gene Symbol: SRD5A1 Name: steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Acc ID: CHEBI:34317 Term: 3,3',4,4',5-pentachlorobiphenyl Definition: A pentachlorobiphenyl that has formula C12H5Cl5. CasRN: 57465-28-8 Chemical ID: MESH:C023035

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3757	6480464	CTD	[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of SRD5A1 protein	PMID:19464308
multiple interactions	ISO	RGD:3757	6480464	CTD	[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of SRD5A1 mRNA	PMID:16984957
decreases expression	ISO	RGD:3757	6480464	CTD	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SRD5A1 mRNA	PMID:20959002