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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP2E1 mRNAPMID:19692669 PMID:23196670
Cyp2e1increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2E1 mRNAPMID:34256052
Cyp2e1multiple interactionsEXP 6480464CTDAHR gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2E1 mRNA]PMID:34256052
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CYP2E1 mRNAPMID:28673560
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