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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2280
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cav1
Name: caveolin 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cav1decreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CAV mRNAPMID:23196670
Cav1multiple interactionsISOCav1 (Mus musculus)6480464CTDCAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; CAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; CAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 mRNA]; CAV1 affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL6 protein]; CAV1 gene mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 gene mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 protein]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein]PMID:19265715 PMID:20406653 PMID:24709675
Cav1multiple interactionsISOCAV1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased expression of FYN protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased expression of KEAP1 protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased phosphorylation of PRKCD protein]; 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in increased phosphorylation of AKT1 protein]PMID:24709675
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