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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:34283
Term: oxybenzone
Definition: A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.
Chemical ID: MESH:C005290
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases expressionEXP 6480464CTDoxybenzone results in increased expression of ESR1 mRNAPMID:32946892
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDoxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 proteinPMID:15458797 PMID:30099065
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDoxybenzone results in increased expression of ESR1 mRNAPMID:30099065
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDoxybenzone binds to and results in increased activity of ESR1 proteinPMID:16079615 PMID:33049310
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