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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1565825
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm4
Name: glutathione S-transferase mu 4
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm4increases expressionISOGstm4 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GSTM4 mRNAPMID:20005886 PMID:21851831
Gstm4multiple interactionsISOGstm4 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM4 mRNA]; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM4 mRNA; Tetrachlorodibenzodioxin promotes the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GSTM4 mRNA]PMID:21851831 PMID:28433925
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