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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:3390
Term: carbaryl
Definition: A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.
Chemical ID: MESH:D012721
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDCarbaryl results in decreased activity of CYP2E1 proteinPMID:22634058
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDCarbaryl inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]PMID:22634058
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