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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:3390
Term: carbaryl
Definition: A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid.
Chemical ID: MESH:D012721
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTDCarbaryl results in increased expression of CYP1A2 proteinPMID:9858662
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDCarbaryl results in decreased activity of CYP1A2 proteinPMID:16790556
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDCarbaryl inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of 2-hydroxyestradiol]; Carbaryl inhibits the reaction [CYP1A2 protein results in increased metabolism of Estradiol]PMID:16790556
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