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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61855 Species: Rattus norvegicus RGD Object: Gene Symbol: Gabra1 Name: gamma-aminobutyric acid (GABA) A receptor, alpha 1

Acc ID: CHEBI:3387 Term: carbamazepine Definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. CasRN: 298-46-4 Chemical ID: MESH:D002220

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Carbamazepine inhibits the reaction [Pilocarpine results in decreased expression of GABRA1 mRNA]	PMID:20821261
increases activity	EXP		6480464	CTD	Carbamazepine results in increased activity of GABRA1 protein	PMID:18717705