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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731977 Species: Mus musculus RGD Object: Gene Symbol: Cflar Name: CASP8 and FADD-like apoptosis regulator

Acc ID: CHEBI:3374 Term: capsaicin Definition: A capsaicinoid that has formula C18H27NO3. CasRN: 404-86-4 Chemical ID: MESH:D002211

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1347509	6480464	CTD	Capsaicin results in decreased expression of CFLAR protein alternative form	PMID:19939880
increases expression	ISO	RGD:1347509	6480464	CTD	Capsaicin results in increased expression of CFLAR mRNA	PMID:19502594